Freddy Ståhlberg
Expert
Investigation of cerebrospinal fluid flow in the cerebral aqueduct using high-resolution phase contrast measurements at 7T MRI
Författare
Summary, in English
Background: The cerebral aqueduct is a central conduit for cerebrospinal fluid (CSF), and non-invasive quantification of CSF flow in the aqueduct may be an important tool for diagnosis and follow-up of treatment. Magnetic resonance (MR) methods at clinical field strengths are limited by low spatial resolution. Purpose: To investigate the feasibility of high-resolution through-plane MR flow measurements (2D-PC) in the cerebral aqueduct at high field strength (7T). Material and Methods: 2D-PC measurements in the aqueduct were performed in nine healthy individuals at 7T. Measurement accuracy was determined using a phantom. Aqueduct area, mean velocity, maximum velocity, minimum velocity, net flow, and mean flow were determined using in-plane resolutions 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm2. Feasibility criteria were defined based on scan time and spatial and temporal resolution. Results: Phantom validation of 2D-PC MR showed good accuracy. In vivo, stroke volume was −8.2 ± 4.4, −4.7 ± 2.8, −6.0 ± 3.8, and −3.7 ± 2.1 µL for 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm2, respectively. The scan with 0.3 × 0.3 mm2 resolution fulfilled the feasibility criteria for a wide range of heart rates and aqueduct diameters. Conclusion: 7T MR enables non-invasive quantification of CSF flow and velocity in the cerebral aqueduct with high spatial resolution.
Avdelning/ar
- Lund University Bioimaging Center
- Diagnostisk radiologi, Lund
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Medicinsk strålningsfysik, Lund
- Hjärt-MR-gruppen i Lund
Publiceringsår
2018
Språk
Engelska
Sidor
988-996
Publikation/Tidskrift/Serie
Acta Radiologica
Volym
59
Issue
8
Dokumenttyp
Artikel i tidskrift
Förlag
SAGE Publications
Ämne
- Radiology, Nuclear Medicine and Medical Imaging
Nyckelord
- Cerebral aqueduct
- cerebrospinal fluid
- magnetic resonance imaging
- pulsatile flow
Status
Published
Forskningsgrupp
- Lund Cardiac MR Group
ISBN/ISSN/Övrigt
- ISSN: 0284-1851