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Freddy Ståhlberg

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Investigation of cerebrospinal fluid flow in the cerebral aqueduct using high-resolution phase contrast measurements at 7T MRI

Författare

  • Karin Markenroth Bloch
  • Johannes Töger
  • Freddy Ståhlberg

Summary, in English

Background: The cerebral aqueduct is a central conduit for cerebrospinal fluid (CSF), and non-invasive quantification of CSF flow in the aqueduct may be an important tool for diagnosis and follow-up of treatment. Magnetic resonance (MR) methods at clinical field strengths are limited by low spatial resolution. Purpose: To investigate the feasibility of high-resolution through-plane MR flow measurements (2D-PC) in the cerebral aqueduct at high field strength (7T). Material and Methods: 2D-PC measurements in the aqueduct were performed in nine healthy individuals at 7T. Measurement accuracy was determined using a phantom. Aqueduct area, mean velocity, maximum velocity, minimum velocity, net flow, and mean flow were determined using in-plane resolutions 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm2. Feasibility criteria were defined based on scan time and spatial and temporal resolution. Results: Phantom validation of 2D-PC MR showed good accuracy. In vivo, stroke volume was −8.2 ± 4.4, −4.7 ± 2.8, −6.0 ± 3.8, and −3.7 ± 2.1 µL for 0.8 × 0.8, 0.5 × 0.5, 0.3 × 0.3, and 0.2 × 0.2 mm2, respectively. The scan with 0.3 × 0.3 mm2 resolution fulfilled the feasibility criteria for a wide range of heart rates and aqueduct diameters. Conclusion: 7T MR enables non-invasive quantification of CSF flow and velocity in the cerebral aqueduct with high spatial resolution.

Avdelning/ar

  • Lund University Bioimaging Center
  • Diagnostisk radiologi, Lund
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • Medicinsk strålningsfysik, Lund
  • Hjärt-MR-gruppen i Lund

Publiceringsår

2018

Språk

Engelska

Sidor

988-996

Publikation/Tidskrift/Serie

Acta Radiologica

Volym

59

Issue

8

Dokumenttyp

Artikel i tidskrift

Förlag

SAGE Publications

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • Cerebral aqueduct
  • cerebrospinal fluid
  • magnetic resonance imaging
  • pulsatile flow

Status

Published

Forskningsgrupp

  • Lund Cardiac MR Group

ISBN/ISSN/Övrigt

  • ISSN: 0284-1851