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Freddy Ståhlberg

Expert

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7-T MR-from research to clinical applications?

Författare

  • Ewald Moser
  • Freddy Ståhlberg
  • Mark E. Ladd
  • Siegfried Trattnig

Summary, in English

Over 20?000 MR systems are currently installed worldwide and, although the majority operate at magnetic fields of 1.5?T and below (i.e. about 70%), experience with 3-T (in high-field clinical diagnostic imaging and research) and 7-T (research only) human MR scanners points to a future in functional and metabolic MR diagnostics. Complementary to previous studies, this review attempts to provide an overview of ultrahigh-field MR research with special emphasis on emerging clinical applications at 7?T. We provide a short summary of the technical development and the current status of installed MR systems. The advantages and challenges of ultrahigh-field MRI and MRS are discussed with special emphasis on radiofrequency inhomogeneity, relaxation times, signal-to-noise improvements, susceptibility effects, chemical shifts, specific absorption rate and other safety issues. In terms of applications, we focus on the topics most likely to gain significantly from 7-T MR, i.e. brain imaging and spectroscopy and musculoskeletal imaging, but also body imaging, which is particularly challenging. Examples are given to demonstrate the advantages of susceptibility-weighted imaging, time-of-flight MR angiography, high-resolution functional MRI, 1H and 31P MRSI in the human brain, sodium and functional imaging of cartilage and the first results (and artefacts) using an eight-channel body array, suggesting future areas of research that should be intensified in order to fully explore the potential of 7-T MR systems for use in clinical diagnosis. Copyright (C) 2011 John Wiley & Sons, Ltd.

Avdelning/ar

  • Diagnostisk radiologi, Lund
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • eSSENCE: The e-Science Collaboration

Publiceringsår

2012

Språk

Engelska

Sidor

695-716

Publikation/Tidskrift/Serie

NMR in Biomedicine

Volym

25

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • skeletal muscle
  • cartilage
  • brain
  • safety
  • ultrahigh-field MR
  • 7-T
  • vascular
  • heart

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0952-3480