Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Default user image.

Katarina Sjögreen Gleisner

Professor

Default user image.

On the biologically effective dose (BED)-using convolution for calculating the effects of repair: II. Numerical considerations.

Författare

  • Johan Ruben Gustafsson
  • Per Nilsson
  • Katarina Sjögreen Gleisner

Summary, in English

We have previously shown analytically that the biologically effective dose (BED), including effects of repair during irradiation and of incomplete repair between fractions, can be formulated using a convolution between the absorbed dose rate function and the function describing repair. In this work, a discrete formalism is derived along with its implementation via the fast Fourier transform. The implementation takes the intrinsic periodicity of the discrete Fourier transform into consideration, as well as possible inconsistencies that may arise due to discretization and truncation of the functions describing the absorbed dose rate and repair. Numerically and analytically calculated BED values are compared for various situations in external beam radiotherapy, brachytherapy and radionuclide therapy, including the use of different repair models. The numerical method is shown to be accurate and versatile since it can be applied to any kind of absorbed dose rate function and allows for the incorporation of different repair models. Typical accuracies for clinically realistic examples are in the order of 10(-3)% to 10(-5)%. The method has thus the potential of being a useful tool for the calculation of BED, also in situations with complicated irradiation patterns or repair functions.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2013

Språk

Engelska

Sidor

1529-1548

Publikation/Tidskrift/Serie

Physics in Medicine and Biology

Volym

58

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

IOP Publishing

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1361-6560