Long-term retention of 177Lu/177mLu-Dotatate in patients investigated by gamma spectrometry and gamma camera imaging.

Summary, in English

Dosimetry in peptide receptor radionuclide therapy using (177)Lu-Dotatate is based on patient imaging during the first week after administration, and determination of the activity retention as a function of time for different tissues. For calculation of the absorbed dose it is generally assumed that the long-term activity retention follows the pattern determined from the first week. This work aims to investigate the validity of this assumption by performing additional patient measurements between 5 and 10 weeks after administration. A further aim is to investigate to what extent absorbed dose values are affected when including these measurements, also taking into account the radionuclide impurity of (177)mLu and build-up of secondary (177)Lu from the (177)mLu decay.

• Författare: Katarina Sjögreen Gleisner; Gustav Brolin; Anna Sundlöv; Edita Mjekiqi; Karl Östlund; Jan Tennvall; Erik Larsson
• Avdelning/ar: Medicinsk strålningsfysik, Lund; Tumörmikromiljö; Medicinsk strålningsfysik, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 976-984
• Publikation/Tidskrift/Serie: Journal of Nuclear Medicine
• Volym: 56
• Issue: 7
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25999429?dopt=Abstract; http://dx.doi.org/10.2967/jnumed.115.155390
• Dokumenttyp: Artikel i tidskrift
• Förlag: Society of Nuclear Medicine
• Ämne: Radiology, Nuclear Medicine and Medical Imaging
• Status: Published
• Forskningsgrupp: Medical Radiation Physics, Malmö
• ISBN/ISSN/Övrigt: ISSN: 0161-5505