Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo

Summary, in English

Access to metabolic information in vivo using magnetic resonance (MR) technologies has generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI). Metabolic fluxes can be studied using the infusion of substrates labeled with magnetic isotopes, with the use of hyperpolarization especially powerful. Unfortunately, these promising methods are not yet accepted clinically, where fast, simple, and reliable measurement and diagnosis are key. Recent advances in functional MRI and chemical exchange saturation transfer (CEST) MRI allow the use of water imaging to study oxygen metabolism and tissue metabolite levels. These, together with the use of novel data analysis approaches such as machine learning for all of these metabolic MR approaches, are increasing the likelihood of their clinical translation.

• Författare: Peter C. M. van Zijl; Kevin Brindle; Hanzhang Lu; Peter B. Barker; Richard Edden; Nirbhay Yadav; Linda Knutsson
• Avdelning/ar: Medicinsk strålningsfysik, Lund; MR Physics
• Publiceringsår: 2021-08-01
• Språk: Engelska
• Sidor: 209-218
• Publikation/Tidskrift/Serie: Current Opinion in Chemical Biology
• Volym: 63
• Länkar: https://linkinghub.elsevier.com/retrieve/pii/S1367593121000892; http://dx.doi.org/10.1016/j.cbpa.2021.06.003
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Radiology, Nuclear Medicine and Medical Imaging; Other Physics Topics
• Status: Published
• Projekt: Natural sugar as an MRI contrast agent for cancer diagnosis
• Forskningsgrupp: MR Physics
• ISBN/ISSN/Övrigt: ISSN: 1367-5931