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X-ray Phase-contrast imaging

Martin Bech

Universitetslektor

X-ray Phase-contrast imaging

Comparison of contrast-to-noise ratios of transmission and dark-field signal in grating-based X-ray imaging for healthy murine lung tissue

Författare

  • Felix Schwab
  • Simone Schleede
  • Dieter Hahn
  • Martin Bech
  • Julia Herzen
  • Sigrid Auweter
  • Fabian Bamberg
  • Klaus Achterhold
  • Ali Oe. Yildirim
  • Alexander Bohla
  • Oliver Eickelberg
  • Rod Loewen
  • Martin Gifford
  • Ronald Ruth
  • Maximilian F. Reiser
  • Konstantin Nikolaou
  • Franz Pfeiffer
  • Felix G. Meinel
Visa allt

Summary, in English

Purpose: An experimental comparison of the contrast-to-noise ratio (CNR) between transmission and dark-field signals in grating-based X-ray imaging for ex-vivo murine lung tissue. Materials and Methods: Lungs from three healthy mice were imaged ex vivo using a laser-driven compact synchrotron X-ray source. Background noise of transmission and dark-field signal was quantified by measuring the standard deviation in a region of interest (ROI) placed in a homogeneous area outside the specimen. Image contrast was quantified by measuring the signal range in rectangular ROIs placed in central and peripheral lung parenchyma. The relative contrast gain (RCG) of dark-field over transmission images was calculated as CNRDF /CNRT. Results: In all images, there was a trend for contrast-to-noise ratios of dark-field images (CNRDF) to be higher than for transmission images (CNRT) for all ROIs (median 61 vs. 38, p = 0.10), but the difference was statistically significant only for peripheral ROIs (61 vs. 32, p = 0.03). Median RCG was >1 for all Rats (1.84). RCG values were significantly smaller for central ROIs than for peripheral ROIs (1.34 vs. 2.43, p = 0.03). Conclusion: The contrast-to-noise ratio of dark-field images compares more favorably to the contrast-to-noise ratio of transmission images for peripheral lung regions as compared to central regions. For any specific specimen, a calculation of the RCG allows comparing which X-ray modality (dark-field or transmission imaging) produces better contrast-to-noise characteristics in a well-defined ROI.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2013

Språk

Engelska

Sidor

236-242

Publikation/Tidskrift/Serie

Zeitschrift für Medizinische Physik

Volym

23

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • Image contrast
  • lung imaging
  • X-ray phase-contrast imaging
  • X-ray
  • dark-field imaging

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1876-4436