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Ronnie Wirestam

Professor

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Towards robust glucose chemical exchange saturation transfer imaging in humans at 3 T: Arterial input function measurements and the effects of infusion time

Författare

  • Anina Seidemo
  • Patrick M. Lehmann
  • Anna Rydhög
  • Ronnie Wirestam
  • Gunther Helms
  • Yi Zhang
  • Nirbhay N. Yadav
  • Pia C. Sundgren
  • Peter C. M. van Zijl
  • Linda Knutsson

Summary, in English

Dynamic glucose-enhanced (DGE) magnetic resonance imaging (MRI) has shown potential for tumor imaging using D-glucose as a biodegradable contrast agent. The DGE signal change is small at 3 T (around 1 and accurate detection is hampered by motion. The intravenous D-glucose injection is associated with transient side effects that can indirectly generate subject movements. In this study, the aim was to study DGE arterial input functions (AIFs) in healthy volunteers at 3 T for different scanning protocols, as a step towards making the glucose chemical exchange saturation transfer (glucoCEST) protocol more robust. Two different infusion durations (1.5 and 4.0 min) and saturation frequency offsets (1.2 and 2.0 ppm) were used. The effect of subject motion on the DGE signal was studied by using motion estimates retrieved from standard retrospective motion correction to create pseudo-DGE maps, where the apparent DGE signal changes were entirely caused by motion. Furthermore, the DGE AIFs were compared with venous blood glucose levels. A significant difference (p = 0.03) between arterial baseline and postinfusion DGE signal was found after D-glucose infusion. The results indicate that the measured DGE AIF signal change depends on both motion and blood glucose concentration change, emphasizing the need for sufficient motion correction in glucoCEST imaging. Finally, we conclude that a longer infusion duration (e.g. 3–4 min) should preferably be used in glucoCEST experiments, because it can minimize the glucose infusion side effects without negatively affecting the DGE signal change.

Avdelning/ar

  • MR Physics
  • Medicinsk strålningsfysik, Lund
  • Lund University Bioimaging Center
  • Neuroradiologi
  • MultiPark: Multidisciplinary research focused on Parkinson´s disease

Publiceringsår

2022

Språk

Engelska

Sidor

4624-4624

Publikation/Tidskrift/Serie

NMR in Biomedicine

Volym

35

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Physics Topics

Nyckelord

  • AIF
  • CEST
  • DGE
  • D-glucose
  • glucoCEST
  • motion correction
  • perfusion

Status

Published

Projekt

  • Natural sugar as an MRI contrast agent for cancer diagnosis

Forskningsgrupp

  • MR Physics
  • Neuroradiology

ISBN/ISSN/Övrigt

  • ISSN: 0952-3480