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Ronnie Wirestam

Professor

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Diffusion-weighted MRI measurements on stroke patients reveal water-exchange mechanisms in sub-acute ischaemic lesions.

Författare

  • Jimmy Lätt
  • Markus Nilsson
  • Danielle van Westen
  • Ronnie Wirestam
  • Freddy Ståhlberg
  • Sara Brockstedt

Summary, in English

The aim of this study was to investigate the diffusion time dependence of signal-versus-b curves obtained from diffusion-weighted magnetic resonance imaging (DW-MRI) of sub-acute ischaemic lesions in stroke patients. In this case series study, 16 patients with sub-acute ischaemic stroke were examined with DW-MRI using two different diffusion times (60 and 260 ms). Nine of these patients showed sufficiently large lesions without artefacts to merit further analysis. The signal-versus-b curves from the lesions were plotted and analysed using a two-compartment model including compartmental exchange. To validate the model and to aid the interpretation of the estimated model parameters, Monte Carlo simulations were performed. In eight cases, the plotted signal-versus-b curves, obtained from the lesions, showed a signal-curve split-up when data for the two diffusion times were compared, revealing effects of compartmental water exchange. For one of the patients, parametric maps were generated based on the extracted model parameters. These novel observations suggest that water exchange between different water pools is measurable and thus potentially useful for clinical assessment. The information can improve the understanding of the relationship between the DW-MRI signal intensity and the microstructural properties of the lesions. Copyright (c) 2009 John Wiley & Sons, Ltd.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund
  • Neuroradiologi
  • Diagnostisk radiologi, Lund

Publiceringsår

2009

Språk

Engelska

Sidor

619-628

Publikation/Tidskrift/Serie

NMR in Biomedicine

Volym

22

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Aktiv

Published

Forskningsgrupp

  • Neuroradiology

ISBN/ISSN/Övrigt

  • ISSN: 0952-3480