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Ronnie Wirestam

Professor

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Phase-based arterial input functions in humans applied to dynamic contrast-enhanced MRI: potential usefulness and limitations

Författare

  • Anders Garpebring
  • Ronnie Wirestam
  • Jun Yu
  • Thomas Asklund
  • Mikael Karlsson

Summary, in English

Object Phase-based arterial input functions (AIFs) provide a promising alternative to standard magnitude-based AIFs, for example, because inflow effects are avoided. The usefulness of phase-based AIFs in clinical dynamic contrast-enhanced MRI (DCE-MRI) was investigated, and relevant pitfalls and sources of uncertainty were identified. Materials and methods AIFs were registered from eight human subjects on, in total, 21 occasions. AIF quality was evaluated by comparing AIFs from right and left internal carotid arteries and by assessing the reliability of blood plasma volume estimates. Results Phase-based AIFs yielded an average bolus peak of 3.9 mM and a residual concentration of 0.37 mM after 3 min, (0.033 mmol/kg contrast agent injection). The average blood plasma volume was 2.7% when using the AIF peak in the estimation, but was significantly different (p < 0.0001) and less physiologically reasonable when based on the AIF tail concentration. Motion-induced phase shifts and accumulation of contrast agent in background tissue regions were identified as main sources of uncertainty. Conclusion Phase-based AIFs are a feasible alternative to magnitude AIFs, but sources of errors exist, making quantification difficult, especially of the AIF tail. Improvement of the technique is feasible and also required for the phase-based AIF approach to reach its full potential.

Avdelning/ar

  • Medicinsk strålningsfysik, Lund

Publiceringsår

2011

Språk

Engelska

Sidor

233-245

Publikation/Tidskrift/Serie

Magma

Volym

24

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • Dynamic contrast-enhanced MRI
  • Arterial input function
  • Phase
  • quantification

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1352-8661