Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation

Summary, in English

Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.

• Författare: Ronnie Wirestam; Christian Engvall; Erik Ryding; Stig Holtas; Freddy Stahlberg; Peter Reinstrup
• Avdelning/ar: Medicinsk strålningsfysik, Lund
• Publiceringsår: 2009
• Språk: Engelska
• Sidor: 2291-2294
• Publikation/Tidskrift/Serie: 2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11
• Dokumenttyp: Konferensbidrag
• Förlag: IEEE - Institute of Electrical and Electronics Engineers Inc.
• Ämne: Radiology, Nuclear Medicine and Medical Imaging
• Nyckelord: magnetic resonance imaging; perfusion; cerebral blood flow; mean; transit time; hypocapnia
• Conference name: 3rd International Conference on Bioinformatics and Biomedical Engineering
• Conference date: 2009-06-11 - 2009-06-16
• Status: Published