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Ronnie Wirestam

Professor

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Absolute quantification of cerebral blood flow: correlation between dynamic susceptibility contrast MRI and model-free arterial spin labeling.

Författare

  • Linda Knutsson
  • Danielle van Westen
  • Esben T Petersen
  • Karin Markenroth Bloch
  • Stig Holtås
  • Freddy Ståhlberg
  • Ronnie Wirestam

Summary, in English

PURPOSE: To compare absolute cerebral blood flow (CBF) estimates obtained by model-free arterial spin labeling (ASL) and dynamic susceptibility contrast MRI (DSC-MRI), corrected for partial volume effects (PVEs). METHODS: CBF was measured using DSC-MRI and model-free ASL (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) at 3 T in 15 subjects with brain tumor, and the two modalities were compared with regard to CBF estimates in normal gray matter (GM) and DSC-to-ASL CBF ratios in selected tumor regions. The DSC-MRI CBF maps were calculated using a global arterial input function (AIF) from the sylvian-fissure region, but, in order to minimize PVEs, the AIF time integral was rescaled by a venous output function time integral obtained from the sagittal sinus. RESULTS: In GM, the average DSC-MRI CBF estimate was 150+/-45 ml/(min 100 g) (mean+/-SD) while the corresponding ASL CBF was 44+/-10 ml/(min 100 g). The linear correlation between GM CBF estimates obtained by DSC-MRI and ASL was r=.89, and observed DSC-to-ASL CBF ratios differed by less than 3% between GM and tumor regions. CONCLUSIONS: A satisfactory positive linear correlation between the CBF estimates obtained by model-free ASL and DSC-MRI was observed, and DSC-to-ASL CBF ratios showed no obvious tissue dependence.

Avdelning/ar

  • MultiPark: Multidisciplinary research focused on Parkinson´s disease
  • Medicinsk strålningsfysik, Lund
  • MR Physics
  • Neuroradiologi
  • Diagnostisk radiologi, Lund

Publiceringsår

2010

Språk

Engelska

Sidor

1-7

Publikation/Tidskrift/Serie

Magnetic Resonance Imaging

Volym

28

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Aktiv

Published

Projekt

  • MRI brain perfusion quantification at 3 tesla using arterial spin labeling
  • Optimisation and Validation of Dynamic Susceptibility Contrast MRI

Forskningsgrupp

  • MR Physics
  • Neuroradiology

ISBN/ISSN/Övrigt

  • ISSN: 1873-5894