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Ceberg

Crister Ceberg

Professor

Ceberg

Comparable survival in rats with intracranial glioblastoma irradiated with single-fraction conventional radiotherapy or FLASH radiotherapy

Författare

  • Emma Liljedahl
  • Elise Konradsson
  • Karin Linderfalk
  • Emma Gustafsson
  • Kristoffer Petersson
  • Crister Ceberg
  • Henrietta Nittby Redebrandt

Summary, in English

Background: Radiotherapy increases survival in patients with glioblastoma. However, the prescribed dose is limited by unwanted side effects on normal tissue. Previous experimental studies have shown that FLASH radiotherapy (FLASH-RT) can reduce these side effects. Still, it is important to establish an equal anti-tumor efficacy comparing FLASH-RT to conventional radiotherapy (CONV-RT). Methods: Fully immunocompetent Fischer 344 rats with the GFP-positive NS1 intracranial glioblastoma model were irradiated with CONV-RT or FLASH-RT in one fraction of 20 Gy, 25 Gy or 30 Gy. Animals were monitored for survival and acute dermal side effects. The brains were harvested upon euthanasia and tumors were examined post mortem. Results: Survival was significantly increased in animals irradiated with CONV-RT and FLASH-RT at 20 Gy and 25 Gy compared to control animals. The longest survival was reached in animals irradiated with FLASH-RT and CONV-RT at 25 Gy. Irradiation at 30 Gy did not lead to increased survival, despite smaller tumors. Tumor size correlated inversely with irradiation dose, both in animals treated with CONV-RT and FLASH-RT. Acute dermal side effects were mild, but only a small proportion of the animals were alive for evaluation of those side effects. Conclusion: The dose response was similar for CONV-RT and FLASH-RT in the present model. Tumor size upon the time of euthanasia correlated inversely with the irradiation dose.

Avdelning/ar

  • Neurokirurgi
  • Medicinsk strålningsfysik, Lund
  • Radiotherapy Physics
  • Reumatologi och molekylär skelettbiologi
  • Human neural utvecklingsbiologi
  • Rausinglaboratoriet i Lund - Tumörsektionen

Publiceringsår

2023

Språk

Engelska

Publikation/Tidskrift/Serie

Frontiers in Oncology

Volym

13

Dokumenttyp

Artikel i tidskrift

Förlag

Frontiers Media S. A.

Ämne

  • Cancer and Oncology

Nyckelord

  • CONV-RT
  • FLASH-RT
  • glioblastoma
  • rat model
  • tumor size

Status

Published

Forskningsgrupp

  • Radiotherapy Physics
  • Human Neural Developmental Biology
  • Rausing laboratory of Lund - Tumor section

ISBN/ISSN/Övrigt

  • ISSN: 2234-943X