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Michael Ljungberg

Michael Ljungberg

Professor

Michael Ljungberg

99mTc/123I Dual-Radionuclide Correction for Self-Scatter, Down-Scatter, and Tailing Effect for a CZT SPECT With Varying Tracer Distributions

Författare

  • Alexandre F. Velo
  • Peng Fan
  • Huidong Xie
  • Xiongchao Chen
  • Nabil Boutagy
  • Attila Feher
  • Albert J. Sinusas
  • Michael Ljungberg
  • Chi Liu

Summary, in English

Single-photon emission computed tomography systems distinguish radionuclides by using multiple energy windows. For cadmium zinc telluride (CZT) detectors, the energy spectrum has a low-energy tail leading to additional crosstalk between the radionuclides. Previous work developed models to correct the scatter and crosstalk for CZT-based dedicated cardiac systems with similar 99mTc/123I tracer distributions. These models estimate the primary and scatter components by solving a set of equations employing the maximum-likelihood expectation–maximization approach. A penalty term is applied to ensure convergence. The present work estimates the penalty term for any 99mTc/123I activity level. An iterative approach incorporating Monte Carlo into the iterative image reconstruction loops was developed to estimate the penalty terms. We used SIMIND and extended cardiac-torso phantoms in this study. Distribution of tracers in the myocardial tissue and blood pool was varied to simulate a dynamic acquisition. Evaluations of the estimated and the real penalty terms were performed using simulations and large animal data. The myocardium to blood pool ratio was calculated using regions of interests in the myocardial tissue and the blood pool for quantitative analysis. All corrected images yielded a good agreement with the gold standard images. In conclusion, we developed a CZT crosstalk correction method for quantitative imaging of 99mTc/123I activity levels by dynamically estimating the penalty terms.

Avdelning/ar

  • Nuclear Medicine Physics

Publiceringsår

2023-11-01

Språk

Engelska

Sidor

839-850

Publikation/Tidskrift/Serie

IEEE Transactions on Radiation and Plasma Medical Sciences

Volym

7

Issue

8

Dokumenttyp

Artikel i tidskrift

Förlag

IEEE - Institute of Electrical and Electronics Engineers Inc.

Ämne

  • Radiology, Nuclear Medicine and Medical Imaging

Nyckelord

  • Cadmium zinc telluride (CZT) detectors
  • down-scatter
  • dual-radionuclide
  • iterative deconvolution model
  • penalty term estimation
  • self-scatter
  • tailing effect corrections

Aktiv

Published

Forskningsgrupp

  • Nuclear Medicine Physics

ISBN/ISSN/Övrigt

  • ISSN: 2469-7311