Michael Ljungberg
Professor
Monte Carlo-based SPECT reconstruction within the SIMIND framework
Författare
Summary, in English
This paper presents the development and validation of a Monte Carlo-based singe photon emission computed tomography reconstruction program for parallel-hole collimation contained within the SIMIND Monte Carlo framework. The Monte Carlo code is used as an accurate forward-projector and is combined with a simplified back-projector to perform iterative tomographic reconstruction using the Maximum Likelihood Expectation Maximization and Ordered Subsets Expectation Maximization algorithms, together forming a program called SIMREC. The Monte Carlo simulation transforms the estimated source distribution directly from activity to counts in its projections. Hence, the reconstructed image is expressed in activity without reference to an external calibration. The program is tested using phantom measurements of spheres filled with 99mTc, 177Lu and 131I placed in air and centrally and peripherally in a water-filled elliptical phantom. The feasibility of applying the reconstruction to patients is also demonstrated for a range of radiopharmaceuticals. The deviation in total activity in the spheres ranged between -4.1% and 6.2% compared with the activity determined when preparing the phantom. The SIMREC program was found to be accurate with respect to activity estimation and to reconstruct visually acceptable images within a few hours when applied to patient examples.
Avdelning/ar
- Nuclear Medicine Physics
Publiceringsår
2018-12-12
Språk
Engelska
Publikation/Tidskrift/Serie
Physics in Medicine and Biology
Volym
63
Issue
24
Dokumenttyp
Artikel i tidskrift
Förlag
IOP Publishing
Ämne
- Radiology, Nuclear Medicine and Medical Imaging
- Other Physics Topics
Nyckelord
- Monte Carlo simulation
- Monte Carlo-based reconstruction
- quantitative SPECT
- SPECT
Status
Published
Forskningsgrupp
- Nuclear Medicine Physics
ISBN/ISSN/Övrigt
- ISSN: 0031-9155