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Michael Ljungberg

Michael Ljungberg


Michael Ljungberg

Multi-centre evaluation of accuracy and reproducibility of planar and SPECT image quantification : An IAEA phantom study


  • Brian E Zimmerman
  • Darko Grošev
  • Irène Buvat
  • Marco A Coca Pérez
  • Eric C Frey
  • Alan Green
  • Anchali Krisanachinda
  • Michael Lassmann
  • Michael Ljungberg
  • Lorena Pozzo
  • Kamila Afroj Quadir
  • Mariella A Terán Gretter
  • Johann Van Staden
  • Gian Luca Poli

Summary, in English

Accurate quantitation of activity provides the basis for internal dosimetry of targeted radionuclide therapies. This study investigated quantitative imaging capabilities at sites with a variety of experience and equipment and assessed levels of errors in activity quantitation in Single-Photon Emission Computed Tomography (SPECT) and planar imaging. Participants from 9 countries took part in a comparison in which planar, SPECT and SPECT with X ray computed tomography (SPECT-CT) imaging were used to quantify activities of four epoxy-filled cylinders containing 133Ba, which was chosen as a surrogate for 131I. The sources, with nominal volumes of 2, 4, 6 and 23mL, were calibrated for 133Ba activity by the National Institute of Standards and Technology, but the activity was initially unknown to the participants. Imaging was performed in a cylindrical phantom filled with water. Two trials were carried out in which the participants first estimated the activities using their local standard protocols, and then repeated the measurements using a standardized acquisition and analysis protocol. Finally, processing of the imaging data from the second trial was repeated by a single centre using a fixed protocol. In the first trial, the activities were underestimated by about 15% with planar imaging. SPECT with Chang's first order attenuation correction (Chang-AC) and SPECT-CT overestimated the activity by about 10%. The second trial showed moderate improvements in accuracy and variability. Planar imaging was subject to methodological errors, e.g., in the use of a transmission scan for attenuation correction. The use of Chang-AC was subject to variability from the definition of phantom contours. The project demonstrated the need for training and standardized protocols to achieve good levels of quantitative accuracy and precision in a multicentre setting. Absolute quantification of simple objects with no background was possible with the strictest protocol to about 6% with planar imaging and SPECT (with Chang-AC) and within 2% for SPECT-CT.


  • Nuclear Medicine Physics
  • Medicinsk strålningsfysik, Lund








Zeitschrift für Medizinische Physik






Artikel i tidskrift




  • Medical Laboratory and Measurements Technologies
  • Radiology, Nuclear Medicine and Medical Imaging
  • Other Physics Topics


  • Humans
  • Image Processing, Computer-Assisted
  • Phantoms, Imaging/standards
  • Radiometry
  • Reproducibility of Results
  • Tomography, Emission-Computed, Single-Photon/methods




  • Nuclear Medicine Physics


  • ISSN: 1876-4436